The Role of Hormones in BPD

[The Wind]

I haven't posted in awhile, because my relationship has been going pretty good. Some minor bumps here and there, but issues that we have been able to work through. The reason I feel that we have been having some success in our relationship is because my wife has been pregnant. We had a beautiful boy in July.

I'm asking the group if anyone has researched hormones and BPD? If so can you point me toward what you may have found?

My wife has been pregnant twice and in each pregnancy her mood would start out pretty rocky, but quickly turn and she'd becomes the most stable version of herself that I've ever seen. She's like a different person, and in a good way. Her mood becomes calm and her thinking is really clear. I suspected it during the first pregnancy and now it's been confirmed in the second pregnancy that her mood and her thinking are generally much more stable while pregnant. That has lead me to believe that hormones play a big role in her mood and her stability.

She had her first period since giving birth last month, and I've seen a change in her behavior since that time. She's become more depressed, more agitated, had less organized thinking, she's stopped doing things around the house, and just had an over all decline in function. This very same thing happened after the birth of our first child. After that birth she declined until she kind of reached her baseline of unpredictability.

I'm here now, because I see the change coming, and I want to get back into that mode of thinking in such a way to be able to best deal with bpd, and because I really want to explore this hormone idea.

Anyone else experienced this? Thought about the role of hormones? Found credible research?

Thanks in advance.

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[Naughty Nibbler]

Hi Wind:
You might find the studies below interesting.

STUDY ABOUT OXYTOCIN PLASMA LEVELS:
Below is the first study investigating oxytocin plasma levels during a social exclusion paradigm showing a reduction of oxytocin plasma levels after social exclusion in BPD patients compared to healthy controls.

https://medicalxpress.com/news/2014-09-hormone-key-borderline-personality-disorder.html

STUDY ABOUT OVARIAN HORMONES:
Ovarian Hormones and Borderline Personality Disorder Features: Preliminary Evidence for Interactive Effects of Estradiol and Progesterone

Highlights

*  We test associations of estradiol and progesterone with weekly borderline features.

*  Estradiol and progesterone interact to predict features for women high in trait BPD.

*  Estradiol deviations predict lower features and symptoms when progesterone is high.

Note:  The info. at the link below is referenced as a preliminary report.  It was polished & that version needs approval in order to view.  I think info. at the link below should be sufficient for what you are looking for.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4516641/#:~:text=Cyclical%20fluctuations%20in%20the%20ovarian,sensitivity%20to%20normal%20hormone%20shifts.